| Rank | Team | Runs Scored | Record |
| 1. | Washington Senators, 1958 | 415 | 42-112 |
| 2. | Chicago Cubs, 1981 | 441 | 41-121 |
| 3. | Boston Braves, 1946 | 449 | 50-104 |
| 4. | Pittsburgh Pirates, 1942 | 458 | 60-94 |
| 5. | Cincinnati Reds, 1942 | 461 | 70-84 |
| 6. | Boston Braves, 1943 | 467 | 53-101 |
| 7. | Los Angeles Dodgers, 1967 | 487 | 67-95 |
| 8. | Baltimore Orioles, 1959 | 490 | 52-102 |
| 9. | Milwaukee Brewers, 1971 | 491 | 51-111 |
| 10. | Los Angeles Dodgers, 1988 | 496 | 62-100 |
| 11. | Los Angeles Dodgers, 1968 | 498 | 66-96 |
| 12. | San Diego Padres, 1969 | 498 | 55-107 |
| 13. | New York Yankees, 1944 | 500 | 45-109 |
| 14. | New York Mets, 1967 | 504 | 51-111 |
| 15. | Boston Braves, 1942 | 510 | 60-94 |
| 16. | Boston Red Sox, 1943 | 512 | 59-95 |
| 17. | Chicago Cubs, 1980 | 513 | 57-105 |
| 18. | New York Mets, 1965 | 518 | 60-102 |
| 19. | Chicago Cubs, 1933 | 520 | 52-102 |
| 20. | Pittsburgh Pirates, 1946 | 520 | 70-84 |
| 21. | Boston Braves, 1952 | 523 | 63-91 |
| 22. | New York Yankees, 1968 | 523 | 74-88 |
| 23. | Montreal Expos, 1972 | 525 | 58-104 |
| 24. | Los Angeles Dodgers, 1992 | 526 | 58-104 |
| 25. | Miami Marlins, 2013 | 526 | 39-123 |
| 26. | Cincinnati Reds, 1968 | 527 | 72-90 |
| 27. | Los Angeles Dodgers, 1989 | 527 | 65-97 |
| 28. | Seattle Mariners, 2011 | 527 | 42-120 |
| 29. | Pittsburgh Pirates, 1943 | 528 | 71-83 |
| 30. | Baltimore Orioles, 1954 | 528 | 59-95 |
| 31. | Washington Senators, 1968 | 528 | 59-103 |
| 32. | New York Mets, 1992 | 528 | 56-106 |
| 33. | St. Louis Browns, 1943 | 529 | 74-80 |
| 34. | Seattle Mariners, 2005 | 529 | 42-120 |
| 35. | Washington Senators, 1967 | 530 | 70-92 |
| 36. | Montreal Expos, 1989 | 533 | 54-108 |
| 37. | St. Louis Cardinals, 1959 | 535 | 59-95 |
| 38. | Pittsburgh Pirates, 1952 | 537 | 64-90 |
| 39. | San Diego Padres, 1972 | 539 | 68-94 |
| 40. | Chicago Cubs, 1985 | 539 | 59-103 |
| 41. | Cincinnati Reds, 1951 | 541 | 67-87 |
| 42. | Texas Rangers, 1972 | 541 | 74-88 |
| 43. | Atlanta Braves, 1974 | 541 | 54-108 |
| 44. | Chicago Cubs, 1978 | 542 | 54-108 |
| 45. | New York Yankees, 1945 | 543 | 54-100 |
| 46. | Philadelphia A's, 1945 | 543 | 57-97 |
| 47. | Pittsburgh Pirates, 1941 | 544 | 65-89 |
| 48. | Chicago White Sox, 1942 | 544 | 69-85 |
| 49. | Chicago White Sox, 1968 | 544 | 77-85 |
| 50. | Seattle Mariners, 2010 | 544 | 40-122 |