| Rank | Team | Wins | Record |
| 1. | Montreal Expos, 1994 | 125 | 125-37 |
| 2. | Montreal Expos, 1980 | 118 | 118-44 |
| 3. | Brooklyn Dodgers, 1952 | 117 | 117-37 |
| 4. | Minnesota Twins, 1969 | 113 | 113-49 |
| 5. | Cincinnati Reds, 1976 | 113 | 113-49 |
| 6. | Montreal Expos, 1993 | 113 | 113-49 |
| 7. | Atlanta Braves, 1998 | 113 | 113-49 |
| 8. | Boston Red Sox, 1948 | 112 | 112-42 |
| 9. | Seattle Mariners, 2001 | 112 | 112-50 |
| 10. | San Diego Padres, 2007 | 112 | 112-50 |
| 11. | Kansas City Royals, 1977 | 111 | 111-51 |
| 12. | Chicago Cubs, 1945 | 110 | 110-44 |
| 13. | San Francisco Giants, 1972 | 110 | 110-52 |
| 14. | Boston Red Sox, 1977 | 110 | 110-52 |
| 15. | Seattle Mariners, 1997 | 110 | 110-52 |
| 16. | Los Angeles Dodgers, 1973 | 109 | 109-54 |
| 17. | Montreal Expos, 1974 | 109 | 109-53 |
| 18. | Boston Red Sox, 1986 | 109 | 109-53 |
| 19. | Seattle Mariners, 1991 | 109 | 109-53 |
| 20. | Boston Red Sox, 2011 | 109 | 109-53 |
| 21. | Chicago White Sox, 1953 | 108 | 108-46 |
| 22. | Cincinnati Reds, 1973 | 108 | 108-55 |
| 23. | Boston Red Sox, 1976 | 108 | 108-54 |
| 24. | Boston Red Sox, 1978 | 108 | 108-54 |
| 25. | Montreal Expos, 1982 | 108 | 108-54 |
| 26. | New York Mets, 1986 | 108 | 108-54 |
| 27. | New York Yankees, 2005 | 108 | 108-54 |
| 28. | Minnesota Twins, 2009 | 108 | 108-54 |
| 29. | San Francisco Giants, 1962 | 107 | 107-55 |
| 30. | San Francisco Giants, 1963 | 107 | 107-55 |
| 31. | San Francisco Giants, 1970 | 107 | 107-55 |
| 32. | Boston Red Sox, 1975 | 107 | 107-55 |
| 33. | New York Mets, 1979 | 107 | 107-55 |
| 34. | Montreal Expos, 1983 | 107 | 107-55 |
| 35. | Atlanta Braves, 1993 | 107 | 107-55 |
| 36. | Chicago Cubs, 2008 | 107 | 107-55 |
| 37. | New York Mets, 1969 | 106 | 106-56 |
| 38. | Cincinnati Reds, 1972 | 106 | 106-56 |
| 39. | Boston Red Sox, 1979 | 106 | 106-56 |
| 40. | Boston Red Sox, 2004 | 106 | 106-56 |
| 41. | Boston Red Sox, 2010 | 106 | 106-56 |
| 42. | Detroit Tigers, 2012 | 106 | 106-56 |
| 43. | New York Yankees, 1950 | 105 | 105-49 |
| 44. | St. Louis Cardinals, 1968 | 105 | 105-57 |
| 45. | New York Yankees, 1980 | 105 | 105-57 |
| 46. | Oakland A's, 1980 | 105 | 105-57 |
| 47. | San Francisco Giants, 1993 | 105 | 105-57 |
| 48. | New York Yankees, 1994 | 105 | 105-57 |
| 49. | Boston Red Sox, 2009 | 105 | 105-57 |
| 50. | New York Yankees, 2010 | 105 | 105-57 |