| Rank | Team | Winning Percentage | Record |
| 1. | Montreal Expos, 1994 | .7716 | 125-37 |
| 2. | Brooklyn Dodgers, 1952 | .7597 | 117-37 |
| 3. | Montreal Expos, 1980 | .7284 | 118-44 |
| 4. | Boston Red Sox, 1948 | .7273 | 112-42 |
| 5. | Chicago Cubs, 1945 | .7143 | 110-44 |
| 6. | Chicago White Sox, 1953 | .7013 | 108-46 |
| 7. | Minnesota Twins, 1969 | .6975 | 113-49 |
| 8. | Cincinnati Reds, 1976 | .6975 | 113-49 |
| 9. | Montreal Expos, 1993 | .6975 | 113-49 |
| 10. | Atlanta Braves, 1998 | .6975 | 113-49 |
| 11. | Seattle Mariners, 2001 | .6914 | 112-50 |
| 12. | San Diego Padres, 2007 | .6914 | 112-50 |
| 13. | Kansas City Royals, 1977 | .6852 | 111-51 |
| 14. | New York Yankees, 1950 | .6818 | 105-49 |
| 15. | San Francisco Giants, 1972 | .6790 | 110-52 |
| 16. | Boston Red Sox, 1977 | .6790 | 110-52 |
| 17. | Seattle Mariners, 1997 | .6790 | 110-52 |
| 18. | Brooklyn Dodgers, 1953 | .6753 | 104-50 |
| 19. | Montreal Expos, 1974 | .6728 | 109-53 |
| 20. | Boston Red Sox, 1986 | .6728 | 109-53 |
| 21. | Seattle Mariners, 1991 | .6728 | 109-53 |
| 22. | Boston Red Sox, 2011 | .6728 | 109-53 |
| 23. | Detroit Tigers, 1946 | .6710 | 104-51 |
| 24. | Los Angeles Dodgers, 1973 | .6687 | 109-54 |
| 25. | Boston Red Sox, 1976 | .6667 | 108-54 |
| 26. | Boston Red Sox, 1978 | .6667 | 108-54 |
| 27. | Montreal Expos, 1982 | .6667 | 108-54 |
| 28. | New York Mets, 1986 | .6667 | 108-54 |
| 29. | New York Yankees, 2005 | .6667 | 108-54 |
| 30. | Minnesota Twins, 2009 | .6667 | 108-54 |
| 31. | Boston Red Sox, 1946 | .6645 | 103-52 |
| 32. | Cincinnati Reds, 1973 | .6626 | 108-55 |
| 33. | Brooklyn Dodgers, 1941 | .6623 | 102-52 |
| 34. | Boston Red Sox, 1942 | .6623 | 102-52 |
| 35. | Brooklyn Dodgers, 1942 | .6623 | 102-52 |
| 36. | St. Louis Cardinals, 1943 | .6623 | 102-52 |
| 37. | St. Louis Cardinals, 1944 | .6623 | 102-52 |
| 38. | Chicago Cubs, 1959 | .6623 | 102-52 |
| 39. | San Francisco Giants, 1962 | .6605 | 107-55 |
| 40. | San Francisco Giants, 1963 | .6605 | 107-55 |
| 41. | San Francisco Giants, 1970 | .6605 | 107-55 |
| 42. | Boston Red Sox, 1975 | .6605 | 107-55 |
| 43. | New York Mets, 1979 | .6605 | 107-55 |
| 44. | Montreal Expos, 1983 | .6605 | 107-55 |
| 45. | Atlanta Braves, 1993 | .6605 | 107-55 |
| 46. | Chicago Cubs, 2008 | .6605 | 107-55 |
| 47. | Detroit Tigers, 1934 | .6558 | 101-53 |
| 48. | Boston Red Sox, 1941 | .6558 | 101-53 |
| 49. | Chicago White Sox, 1952 | .6558 | 101-53 |
| 50. | New York Yankees, 1956 | .6558 | 101-53 |