| Rank | Team | Earned Run Average | Record |
| 1. | St. Louis Cardinals, 1968 | 2.5375 | 105-57 |
| 2. | Detroit Tigers, 1968 | 2.6296 | 99-63 |
| 3. | Brooklyn Dodgers, 1942 | 2.6348 | 102-52 |
| 4. | New York Mets, 1969 | 2.6352 | 106-56 |
| 5. | St. Louis Cardinals, 1943 | 2.6405 | 102-52 |
| 6. | San Diego Padres, 1978 | 2.6659 | 101-61 |
| 7. | Chicago White Sox, 1967 | 2.6988 | 88-74 |
| 8. | Boston Red Sox, 1942 | 2.7214 | 102-52 |
| 9. | Chicago White Sox, 1952 | 2.7261 | 101-53 |
| 10. | Los Angeles Dodgers, 1973 | 2.7335 | 109-54 |
| 11. | San Francisco Giants, 1968 | 2.7371 | 103-59 |
| 12. | Chicago White Sox, 1943 | 2.7390 | 87-67 |
| 13. | Cincinnati Reds, 1943 | 2.7577 | 90-64 |
| 14. | Pittsburgh Pirates, 1968 | 2.7612 | 80-82 |
| 15. | Washington Senators, 1945 | 2.7701 | 85-69 |
| 16. | Los Angeles Dodgers, 1965 | 2.7749 | 84-78 |
| 17. | Baltimore Orioles, 1968 | 2.7886 | 82-80 |
| 18. | Washington Senators, 1942 | 2.7978 | 84-70 |
| 19. | Cincinnati Reds, 1974 | 2.8080 | 100-62 |
| 20. | Brooklyn Dodgers, 1952 | 2.8182 | 117-37 |
| 21. | Pittsburgh Pirates, 1991 | 2.8216 | 103-59 |
| 22. | New York Mets, 1968 | 2.8269 | 87-75 |
| 23. | Washington Senators, 1952 | 2.8279 | 84-70 |
| 24. | St. Louis Cardinals, 1967 | 2.8389 | 98-64 |
| 25. | Boston Red Sox, 1976 | 2.8539 | 108-54 |
| 26. | Montreal Expos, 1980 | 2.8586 | 118-44 |
| 27. | San Diego Padres, 2007 | 2.8593 | 112-50 |
| 28. | Montreal Expos, 1992 | 2.8594 | 96-66 |
| 29. | Cincinnati Reds, 1976 | 2.8695 | 113-49 |
| 30. | New York Mets, 1988 | 2.9002 | 104-58 |
| 31. | Pittsburgh Pirates, 1943 | 2.9021 | 71-83 |
| 32. | Oakland A's, 1968 | 2.9087 | 84-78 |
| 33. | Boston Red Sox, 1986 | 2.9142 | 109-53 |
| 34. | Cincinnati Reds, 1967 | 2.9222 | 103-59 |
| 35. | Detroit Tigers, 1943 | 2.9317 | 73-81 |
| 36. | Detroit Tigers, 1946 | 2.9384 | 104-51 |
| 37. | Washington Senators, 1943 | 2.9405 | 85-69 |
| 38. | Montreal Expos, 1982 | 2.9413 | 108-54 |
| 39. | Cincinnati Reds, 1964 | 2.9453 | 98-65 |
| 40. | Washington Senators, 1954 | 2.9462 | 87-67 |
| 41. | New York Yankees, 1943 | 2.9481 | 88-66 |
| 42. | San Francisco Giants, 1966 | 2.9525 | 98-64 |
| 43. | Cincinnati Reds, 1972 | 2.9558 | 106-56 |
| 44. | San Diego Padres, 1984 | 2.9591 | 104-58 |
| 45. | Montreal Expos, 1985 | 2.9627 | 101-61 |
| 46. | Washington Senators, 1944 | 2.9645 | 95-59 |
| 47. | Cincinnati Reds, 1946 | 2.9662 | 87-67 |
| 48. | Atlanta Braves, 1968 | 2.9682 | 74-88 |
| 49. | Los Angeles Dodgers, 1976 | 2.9692 | 77-85 |
| 50. | San Francisco Giants, 1989 | 2.9713 | 91-71 |